Language Select
Varian Logo

VARIAN MEDICAL AFFAIRS

Engaging with clinicians around the world to exchange meaningful information and advance clinical research.
Advanced Search
  • Jul 30, 2018
    Safety and Clinical Activity of Immunotherapy and Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors

    Immunotherapy continues to revolutionize the treatment of metastatic cancer with expanding applications across many tumor types. There is significant interest in combining radiation therapy with immunotherapy to potentially enhance immune responses and trigger abscopal effects. While there is some thought that SBRT may be particularly effective at triggering immune responses when compared with conventional fractionation, the safety of combining SBRT with immunotherapy and the number of lesions that should be treated remains unclear. In this prospective phase I trial of patients who had progressed on standard therapies, SBRT followed by pembrolizumab appeared to be safe. The overall response rate was encouraging in this population of patients not selected forPD-L1 expression, providing preliminary support for tumor debulking with SBRT and possible evidence of synergism. Furthermore, the correlation of interferon-gamma gene expression after SBRT with the development of abscopal responses suggests that this maybe a helpful biomarker for future studies. Ultimately, the progression-free and overall survival in this heterogenous group of patients with metastatic disease remains poor, and this approach will need to be tested in randomized trials.

    PDF

    Journal & Date: J Clin Oncol. 2018 Jun 1;36(16):1611-1618
    Key Institution: University of Chicago, Chicago, USA
    Keywords: SBRT, Immunotherapy, Metastatic, Solid Tumors, Clinical Trial

FOR EDUCATIONAL AND SCIENTIFIC EXCHANGE ONLY – NOT FOR SALES OR PROMOTIONAL USE.

 

  • Follow Us

Production of any of the material contained herein in any format or media without the express written permission of Varian Medical Systems is prohibited.

Varian Logo